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研究実績・活動実績

研究活動

  1. 2018年度医療技術等国際展開推進事業、ベトナム北部地域における健康診断普及プロジェクト、研修実施機関
  2. 日本医療研究開発機構(AMED) 循環器疾患・糖尿病等生活習慣病対策実用化研究事業(2016年度~2018年度)、食-腸-医をつなぐ生活習慣病の新規メカニズムの解明と腸内細菌叢やその代謝産物に着目した病態制御法の開発
    研究開発分担者:井上 博睦 (研究協力者:呂 軍

学会発表

  1. 井上博睦、呂軍、橋本真紀子、林裕子、久保幸子.
    当施設におけるベトナム人通訳の教育実績と、今後の外国語対応の在り方について.
    第60回日本人間ドック学会学術大会(2019年 7月26日、岡山、口頭発表、演題番号:2-6-03)
  2. 呂軍、井上博睦、林裕子、橋本真紀子、久保幸子.
    ヘリコバクターピロリ感染とHDLコレステロール値の関係.
    第60回日本人間ドック学会学術大会(2019年 7月25日、岡山、口頭発表、演題番号:1-4-18)
  3. 呂 軍、井上 博睦、林 裕子、橋本 真紀子.
    国際的人間ドックを目指した取り込みと課題(2) ・2017年度の総括.
    第59回日本人間ドック学会学術大会(2018年 8月31日、新潟、口頭発表、演題番号:2-11-26) 
  4. 呂 軍、井上 博睦、林 裕子、橋本 真紀子、矢野 哲.
    国際的人間ドックを目指した取り込みと課題.
    第58回日本人間ドック学会学術大会(2017年8月25日、大宮、口頭発表、演題番号:2-8-04)

論文発表

  1. Tomoki Takashina, Takayoshi Koyama, Satoshi Nohara, Masakatsu Hasegawa, Akira Ishiguro, Kenta Iijima, Jun Lu, Mari Shimura, Tadashi Okamoto, Tetsushi Sakuma, Takashi Yamamoto, Yukihito Ishizaka, Identification of a cell-penetrating peptide applicable to a protein-based transcription activator-like effector expression system for cell engineering. Biomaterials, 2018 Aug;173:11-21.
  2. Hiroshi Higuchi, Natsuko Yamakawa, Ken-Ichi Imadome, Takashi Yahata, Ryutaro Kotaki, Jun Ogata, Masatoshi Kakizaki, Koji Fujita, Jun Lu, Kazuaki Yokoyama, Kazuki Okuyama, Ai Sato, Masako Takamatsu, Natsumi Kurosaki, Syakira Mohamad Alba, Azran Azhim, Ryouichi Horie, Toshiki Watanabe, Toshio Kitamura, Kiyoshi Ando, Takao Kashiwagi, Toshimitsu Matsui, Akinao Okamoto, Hiroshi Handa, Masahiko Kuroda, Naoya Nakamura and Ai Kotani, Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma, Blood, 2018 Apr 22.
  3. Takashi Inoue, Yukihito Ishizaka, Emi Sasaki, Jun Lu, Takayuki Mineshige, Mikio Yanase, Erika Sasaki, Masayuki Shimoda, Thioacetamide-induced hepatic fibrosis in the common marmoset, Experimental Animals, 2018 Feb 21.
  4. Jun Lu*, Haruna Yamamoto*, Shigeyoshi Oba, Toyotaka Kawamata, Akihide Yoshimi, Natsumi Kurosaki, Kazuaki Yokoyama, Hiromichi Matsushita, Mineo Kurokawa, Arinobu Tojo, Kiyoshi Ando, Kazuhiro Morishita, Koko Katagiri, and Ai Kotani, miR-133 regulates Evi1 expression in AML cells as a potential therapeutic target, Scientific Reports, 2016 Jan 12;6:19204. (*Equally contributed) 
  5. Hidetsugu Kawai, Hiromichi Matsushita, Rikio Suzuki, Yin Sheng, Jun Lu, Hideyuki Matsuzawa, Takashi Yahata, Mitsuyo Tsuma-Kaneko, Hideo Tsukamoto, Hiroshi Kawada, Yoshiaki Ogawa, Kiyoshi Ando, Functional analysis of the SEPT9-ABL1 chimeric fusion gene derived from T-prolymphocytic leukemia, Leukemia Research, 38(12):1451-9, 2014
  6. Kazuki Okuyama, Tomokatsu Ikawa, Bernhard Gentner, Katsuto Hozumi, Ratanakanit Harnprasopwat, Jun Lu, Riu Yamashita, Daon Ha, Takae Toyoshima, Bidisha Chanda, Toyotaka Kawamata, Kazuaki Yokoyama, Shusheng Wang, Kiyoshi Ando, Harvey F. Lodish, Arinobu Tojo, Hiroshi Kawamoto, and Ai Kotani, MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors, Proceedings of the National Academy of Sciences of the United States of America, 110(33):13410-5, 2013
  7. Jun Lu*, Toyotaka Kawamata*, Tadayuki Sato*, Masafumi Tanaka, Hitoshi Nagaoka, Yasutoshi Agata, Takae Toyoshima, Kazuaki Yokoyama, Naoki Oyaizu, Naoya Nakamura, Kiyoshi Ando, Arinobu Tojo and Ai Kotani, Imatinib mesylate directly impairs class switch recombination through downregulation of AID: its potential efficacy as an AID suppressor, Blood, 119, 3123-3127, 2012. (*Equally contributed)
  8. Jun Lu*, Bidisha Chanda* and Ai Kotani*, EBV encoded miRNAs in EBV related malignancy, Hematology Science and Practice (Book), 16, 409-424, 2012. (*Equally contributed)
  9. Hiromu Inoue, Sho Yamazaki, Maki Shimizu, Hiroshi Uozaki, Tadashi Goto, Shin Ohnishi, and Kazuhiko Koike, Liver Injury Induced by the Japanese Herbal Drug Kamishoyosan, Gastroenterology & Hepatology, 7(10): 692–695, 2011
  10. Sachiko Seo, Tetsuya Nakamoto, Masataka Takeshita, Jun Lu, Tomohiko Sato, Takahiro Suzuki, Yasuhiko Kamikubo, Motoshi Ichikawa, Masaki Noda, Seishi Ogawa, Hiroaki Honda, Hideaki Oda, Mineo Kurokawa, Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl, Cancer Science, 102, 2109-2117, 2011
  11. Inoue Hiromu, Miyatani H, Nakashima Y, Sagihara N, Yoshida Y, Successful endoscopic mucosal resection of a hyperplastic polyp in a hemophilia A patient, Digestive Endoscopy, 23(4):325, 2011
  12. Jun Lu, Chika Arai, Abu Bakar Md. and Masataka Ihara, Plasmodium berghei proteome changes in response to SSJ-183 treatment, Bioorganic & Medicinal Chemistry, 19, 4144-4147, 2011
  13. Toshikazu Suzuki, Jun Lu, Gaofeng Hu, Kazuko Kita and Nobuo Suzuki, Retrovirus-mediated transduction of a short hairpin RNA gene for GRP78 fails to downregulate GRP78 expression but leads to cisplatin sensitization in HeLa cells, Oncology Reports, 25, 879-885, 2011
  14. Yoriko Tokita, Kentaro Kaji, Jun Lu, Yoshio Okura, Kuniko Kohyama, Yoh Matsumoto, Assessment of Non-Viral Amyloid-b DNA Vaccines on Amyloid-b Reduction and Safety in Rhesus Monkeys, Journal of Alzheimer’s Disease, 22, 1351-1361, 2010
  15. Jian-Feng Ge, Chika Arai, Mei Yang, Abu Bakar Md., Jun Lu, Nasser S. Mohammad, Sergio Wittlin, Marcel Kaiser, Reto Brun, Karen White, Susan A. Charman, Isamu Itoh, and Masataka Ihara, Discovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for Malaria, American Chemical Society Medicinal Chemistry Letters, 1, 360-364, 2010
  16. Mei Yang, Chika Arai, Abu Bakar Md., Jun Lu, Jian-Feng Ge, Khanitha Pudhom, Kiyosei Takasu, Kazuki Kasai, Marcel Kaiser, Reto Brun, Vanessa Yardley, Isamu Itoh and Masataka Ihara, Fluorinated Rhodacyanine (SJL-01) Possessing High Efficacy for Visceral Leishmaniasis (VL), Journal of Medicinal Chemistry, 53, 368-373, 2010
  17. Jun Lu, Toshikazu Suzuki, Sa Lu, Nobuo Suzuki, Involvement of glyceraldehyde-3- phosphate dehydrogenase in X-ray resistance of HeLa cells, Bioscience, Biotechnology, and Biochemistry, 72, 2432-2435, 2008
  18. Jun Lu, Toshikazu Suzuki, Mamoru Satoh, Shiping Chen, Takeshi Tomonaga, Fumio Nomura, Nobuo Suzuki, Involvement of aldolase A in X-ray resistance of human HeLa and UVr-1 cells. Biochemical and Biophysical Research Communications, 369, 948-952, 2008
  19. Hiromu Inoue, Yukihisa Sawada, Kaori Ochiai, Hideaki Honda, Junko Murayama, Yasutaka Kudo, Yoshiyuki Nakashima, Noriyoshi Sagihara, Hiroyuki Miyatani, Ikuo Nakamura, Yukio Yoshida, Hepatocellular carcinoma with direct invasion to the stomach, Internal Medicine, 46(12):845-8, 2007
  20. Toshikazu Suzuki, Jun Lu, Muhammed A. M. Zahed, Kazuko Kita, Nobuo Suzuki, Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells, Archives of Biochemistry and Biophysics, 468, 1-14, 2007
  21. Inoue Hiromu, Yasu T, Kawahito K, Kubo N, Nishida J, Kawakami M, Saito M, Successfully treated massive pulmonary thromboembolism and thrombus in the right atrium due to diffuse malignant lymphoma: a case report, Journal of Cardiology, 48(3):159-63, 2006
  22. Hiromu Inoue, Hiroyuki Miyatani, Yukihisa Sawada, Yukio Yoshida, A case of pancreas cancer with autoimmune pancreatitis, Pancreas, 33(2):208-9, 2006
  23. Hisayo Kubota, Toshikazu Suzuki, Jun Lu, Shunji Takahashi, Katsuo Sugita, Souei Sekiya, Nobuo Suzuki, Increased expression of GRP94 protein is associated with decreased sensitivity to X-ray in cervical cancer cell lines, International Journal of Radiation Biology, 81, 701-709, 2005
  24. Hong-Chang Zhang, Kiyonobu karata, Kazuyuki Matushita, Shunji Takahashi, Xiao-bo Tong, Jun Lu, Chang-Lin Zhu, Shigeru Sugaya, Toshikazu Suzuki, Nobuo Suzuki, Leupeptin-sensitive proteases involved in cell survival after X-ray irradiation in human RSa cells, Cell Biology International, 29, 662-668, 2005